Sign 216 marks a motorway, and pedestrians are not allowed to enter one. Traffic on it is fast and it is meant for vehicles, so walking there puts both the pedestrian and the drivers in danger. The other signs in the picture do not forbid entry to pedestrians.
Topic: Traffic signs. The bank marks it for these classes: Light truck (C1), Heavy truck (C), Bus (D), Motorcycle (A), Tractor (1), Private car (B).